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. 2014 Dec 30;15(1):412. doi: 10.1186/s12859-014-0412-0

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© Joshi; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ES hotspots are preferentially occupied by activators. A. Overlap of genes in three groups in ES Ng dataset with up- and down-regulated genes upon Oct4 knockdown in ES cells showing hotspots were enriched for only down-regulated genes. B. Fraction of up- and down-regulated genes upon Dnmt and Set1db knock out in three groups in ES Ng dataset showing hotspot enrichment only in Set1db KO down-regulated genes.