Table 2.
Mean parameter estimates and bootstrap mean (95% confidence interval) estimates for the final covariate model
| Parameter | Model | Bootstrap | ||
|---|---|---|---|---|
| Mean | Mean | 95% confidence interval | ||
| 2.5% | 97.5% | |||
| Fixed effects | ||||
| CL (L/h) | 5.1 | 5.4 | 3.7 | 7.4 |
| Vc (L) | 18.7 | 18.2 | 13.0 | 21.0 |
| Vp (L) | 13.2 | 13.6 | 11.3 | 15.9 |
| Q (L/h) | 21.0 | 24.2 | 12.8 | 37.0 |
| CLCRCL | 1.89 | 1.85 | 0.99 | 2.65 |
| Random effects BSV (% CV) | ||||
| CL (L/h) | 51.6 | 52.2 | 37.9 | 66.6 |
| Vc (L) | 45.8 | 48.4 | 32.1 | 69.9 |
| Vp (L) | 28.7 | 16.2 | 0.2 | 42.1 |
| Random error | ||||
| RUV (% CV) | 13.7 | 13.3 | 10.1 | 17.6 |
| RUV (SD, mg/L) | 2.3 | 1.87 | 1.02 | 2.70 |
CL, clearance; Vc, volume of distribution of the central compartment; Vp, volume of distribution of the peripheral compartment; Q, inter-compartmental clearance; CLCRCL, the fractional effect of CrCL on CL for patients not receiving RRT; BSV, between-subject variability; RUV, residual unexplained variability.