Table 3.
The effect of changing creatinine clearance on mean (50 th percentile) and 10 th percentile trough concentrations from the simulated ECMO patients (n = 1,000) receiving various meropenem doses
| Dose | ||||
|---|---|---|---|---|
| Creatinine clearance | Concentration percentile | 500 mg 8-hrly | 1 g 8-hrly | 2 g 8-hrly |
| 20 | 50th | 18.9 | 26.4 | 76.4 |
| 10th | 3.6 | 16.2 | 14.6 | |
| 50 | 50th | 14.5 | 19.7 | 58.8 |
| 10th | 2.6 | 9.8 | 10.5 | |
| 80 | 50th | 10.0 | 14.8 | 39.7 |
| 10th | 1.3 | 4.8 | 5.1 | |
| 120 | 50th | 7.6 | 11.1 | 30.0 |
| 10th | 0.7 | 2.5 | 2.7 | |
| 180 | 50th | 5.6 | 7.9 | 21.7 |
| 10th | 0.4 | 0.7 | 0.9 |
These simulations assume that no significant accumulation of meropenem occurred in study population. ECMO, extracorporeal membrane oxygenation.