Table 1.
Gene set and KEGG enrichment analysis of the consensus heat-stress response at T c,Max
| Function * | Transcript ID | Type * | Heart ES | Liver ES | Kidney ES | Lung ES |
|---|---|---|---|---|---|---|
| Protein folding/unfolding response | ||||||
| Protein folding | 6457 | BP | 23.5 | 10.9 | 13.3 | 39.8 |
| Unfolded protein binding | 51082 | MF | 14.4 | 12.0 | 16.0 | 32.7 |
| Heat-shock protein binding | 31072 | MF | 13.4 | 5.8 | 7.3 | 15.9 |
| Response to heat | 9408 | BP | 9.3 | 15.2 | 10.7 | 13.6 |
| Chaperone binding | 51087 | MF | 7.6 | 8.6 | 12.7 | 8.5 |
| Response to unfolded protein | 6986 | BP | 7.3 | 14.9 | 19.9 | 19.1 |
| Response to apoptosis | ||||||
| Positive regulation of apoptotic process | 43065 | BP | 11.8 | 12.3 | 9.3 | 12.5 |
| Negative regulation of neuron apoptotic process | 43524 | BP | 7.9 | 8.3 | 7.5 | 7.7 |
| Response to LPS/cytokines | ||||||
| Response to lipopolysaccharide | 32496 | BP | 5.7 | 10.1 | 3.2 | 11.1 |
| Response to cytokine stimulus | 34097 | BP | 4.8 | 6.2 | 4.5 | 15.5 |
| Transcriptional Response/Other | ||||||
| RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 1077 | MF | 15.4 | 6.6 | 10.5 | 6.1 |
| Response to cAMP | 51591 | BP | 10.7 | 3.1 | 5.5 | 4.8 |
| Double-stranded DNA binding | 3690 | MF | 8.4 | 7.0 | 8.5 | 7.8 |
| Response to mechanical stimulus | 9612 | BP | 8.3 | 5.6 | 5.1 | 4.6 |
| Response to hydrogen peroxide | 42542 | BP | 7.9 | 6.6 | 8.1 | 5.9 |
| Transcription factor complex | 5667 | CC | 7.5 | 4.8 | 5.6 | 5.0 |
| Positive regulation of smooth muscle cell proliferation | 48661 | BP | 6.2 | 3.6 | 6.1 | 4.9 |
| Response to glucocorticoid stimulus | 51384 | BP | 5.8 | 11.5 | 4.8 | 3.9 |
| Negative regulation of transcription from RNA polymerase II promoter | 122 | BP | 5.8 | 6.0 | 7.0 | 4.8 |
| Response to hypoxia | 1666 | BP | 5.5 | 8.4 | 7.8 | 12.3 |
| Response to estrogen stimulus | 43627 | BP | 5.5 | 5.9 | 8.1 | 4.7 |
| Cell surface | 9986 | CC | 5.1 | 7.0 | 4.8 | 6.7 |
| Positive regulation of angiogenesis | 45766 | BP | 4.8 | 6.6 | 8.7 | 10.8 |
| Response to light stimulus | 9416 | BP | 3.8 | 7.6 | 10.4 | 6.0 |
| Response to drug | 42493 | BP | 3.7 | 7.8 | 6.9 | 3.2 |
| MAPK Pathway | rno04010 | KEGG | 5.0 | 2.8 | 5.3 | 3.3 |
*GO terms significantly enriched in liver, kidney, heart, and lung (25 common to all organs out of 467 enriched terms at Tc,Max). BP, biological processes; cAMP, cyclic adenosine monophosphate; CC, cellular components; ES, enrichment score; KEGG, Kyoto Encyclopedia of Genes and Genomes pathway; LPS, lipopolysaccharide; MAPK, mitogen-associated protein kinase; MF, molecular functions; Tc,Max, maximum core temperature.