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HGF-induced single cell motility is mediated by the Ser/Thr kinases JNK and MAP4K4. (A) Motility of single cells migrating on flat 2D surfaces in the absence or presence of HGF (20 ng/mL) and the JNK inhibitor SP665757 (10 ng/mL). Box plots of three independent experiments are shown. (B) Same experimental approach as in (A) but instead of using a pharmacological inhibitor, MAP4K4 was depleted from cells using validated MAP4K4-specific (+) siRNA. (−) is a negative control siRNA .
