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(A–D) D1 and D4 are electrostatically attracted when Ser-108 is phosphorylated (A and C), but repelled when it is dephosphorylated (B and D). (A and B) D1–D4 are colored green, yellow, cyan, and pink, respectively. (A–D) Electrostatic field lines of Apo-P (A and C) and Apo-deP (B and D). (C and D) Expansions of the catalytic cleft highlight attraction and repulsion between D1 and D4 in the red and blue boxes, respectively. To see this figure in color, go online.
