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Simulated data comparison between cMDH and mMDH in the reverse direction with no products present (A–I): NADH and OAA concentrations were as indicated in the individual plots; the activity of mMDH (represented by solid black line) is lower compared to cMDH (represented by solid gray line) for low [OAA], whereas the mMDH activity is higher compared to cMDH for higher [OAA].
