Table 3.

Frequency of Mutations by Age at Diagnosis and Family History of Breast or Ovarian Cancer

Family Cancer History	Age at TNBC Diagnosis (years)
	< 35			35 to 39			40 to 49			50 to 59			≥ 60
	Mutation Carriers	All Patients	%	Mutation Carriers	All Patients	%	Mutation Carriers	All Patients	%	Mutation Carriers	All Patients	%	Mutation Carriers	All Patients	%
BRCA1
No breast, no ovarian	14	91	15.4	15	149	10.1	14	209	6.7	13	241	5.4	4	279	1.4
One relative with breast, no ovarian	6	48	12.5	7	50	14	11	103	10.7	3	80	3.8	2	79	2.5
≥ Two relatives with breast, no ovarian	4	12	33.3	5	16	31.3	7	38	18.4	2	28	7.1	1	23	4.3
Any relative with ovarian	3	5	60	6	15	40	6	18	33.3	9	17	52.9	0	7	0
Total	27	156	17.3	33	230	14.3	38	368	10.3	27	366	7.4	7	388	1.8
BRCA2
No breast, no ovarian	4	91	4.4	8	149	5.4	4	209	1.9	5	241	2.1	2	279	0.7
Any relative with breast, no ovarian	3	60	5	1	66	1.5	4	141	2.8	2	108	1.9	2	102	2
Any relative with ovarian	0	5	0	2	15	13.3	1	18	5.6	1	17	5.9	1	7	14.3
Total	7	156	4.5	11	230	4.8	9	368	2.4	8	366	2.2	5	388	1.3
BRCA1 and BRCA2
No breast, no ovarian	18	91	19.8	23	149	15.4	18	209	8.6	18	241	7.5	6	279	1.4
One relative with breast, no ovarian	7	48	14.6	7	50	14	14	103	13.6	5	80	6.3	4	79	5.1
≥ Two relatives with breast, no ovarian	6	12	50	6	16	37.5	8	38	21	2	28	7.1	1	23	0
Any relative with ovarian	3	5	60	8	15	53.3	7	18	38.9	10	17	58.8	1	7	14.3
Total	34	156	21.8	44	230	19.1	47	368	12.8	35	366	9.6	12	388	3.1
Other genes
No breast, no ovarian	3	91	3.3	6	149	4	10	209	4.8	7	241	2.9	7	279	2.5
Any relative with breast, no ovarian	2	60	3.3	4	66	6.1	6	141	4.3	6	108	5.6	2	102	2
Any relative with ovarian	0	5	0	0	15	0	0	18	0	1	17	5.9	0	7	0
Total	5	156	3.2	10	230	4.3	16	368	4.3	14	366	3.8	9	388	2.3
All genes
No breast, no ovarian	21	91	23.1	29	149	19.5	27	209	12.9	25	241	10.4	13	279	4.7
One relative with breast, no ovarian	9	48	18.8	9	50	18	18	103	17.5	9	80	11.3	5	79	6.3
≥ Two relatives with breast, no ovarian	6	12	50	7	16	43.8	10	38	26.3	4	28	14.3	2	23	8.7
Any relative with ovarian	3	5	60	8	15	53.3	7	18	38.9	11	17	64.7	1	7	14.3
Total	39	156	20.0	53	230	23.0	62	368	16.8	49	366	13.4	21	388	5.4

NOTE. Patients with TNBC for whom information was lacking on age at cancer diagnosis or family history of cancer were excluded.

Abbreviation: TNBC, triple-negative breast cancer.