Table 2.

Comparisons of the voxel content and magnetic resonance spectroscopy (MRS) measures relative to total creatine (mean ± SD) for glutathione, GABA, glutamate and glutamine, across both patients and controls, corrected for grey matter content

	Patients	Healthy	Significance value
Grey matter	0.38 ± 00.072	0.421 ± 0.070	(t(28) = 2.191, p = 0.033
White matter	0.510 ± 0.056	0.490 ± 0.053	(t(28) = −1.422, p = 0.161
CSF	0.109 ± 0.047	0.089 ± 0.032	(t(28) = −1.912, p = 0.061
GSH	0.174 ± 0.013	0.183 ± 0.014	F = 5.098, p = 0.028
GABA	0.225 ± 0.034	0.237 ± 0.053	F = 0.507, p = 0.33
Glutamate	0.890 ± 0.085	0.880 ± 0.090	F = 0.001, p = 0.97
Glutamine	0.192 ± 0.036	0.187 ± 0.030	F = 0.008, p = 0.93