. 2014 Aug 15;232(3):605–621. doi: 10.1007/s00213-014-3704-1

Table 2.

Receptor binding selectivity of ITI-007 in vitro as measured against a broad specificity profile panel: off-target receptor interactions with >50 % binding at a 100 nM concentration of ITI-007 (of a total of 66 substrates evaluated)

Substrate	% Inhibition of binding at 100 nM concentration^a
Adrenergic, 1β	85.43
Adrenergic, α₁	66.06
Dopamine, D₄	64.27

^aValues are expressed as the percent inhibition of specific binding and represent the average of replicate tubes at the specified drug concentration