Table 3.
Effect of acute (2 h) or chronic (21 day) daily treatment with haloperidol, risperidone, aripiprazole, or ITI-007 on HVA/DA and DOPAC/DA ratios in rat striatal tissue
| Compound (dose in mg/kg) | Acute (2 h) dosing | Chronic (21 day) dosing | ||||||
|---|---|---|---|---|---|---|---|---|
| HVA/DA | DOPAC/DA | HVA/DA | DOPAC/DA | |||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Vehicle (0) | 6.59 | 0.62 | 4.58 | 0.51 | 7.04 | 0.41 | 3.61 | 0.81 |
| Haloperidol (3) | 28.14*,**,*** | 2.08 | 22.68*,**,*** | 2.80 | 24.15*,**,*** | 4.89 | 17.00*,**,*** | 3.94 |
| Haloperidol (1) | 31.04*,**,*** | 1.84 | 19.69*,**,*** | 1.45 | 29.23*,**,*** | 4.85 | 18.26*,**,*** | 2.21 |
| Risperidone (10) | 23.06*,**,*** | 3.80 | 30.98*,**,*** | 2.68 | 36.39*,**,*** | 0.54 | 25.12*,**,*** | 1.91 |
| Risperidone (1) | 30.71*,**,*** | 1.86 | 14.35*,**,*** | 2.46 | 29.37*,**,*** | 2.26 | 16.35*,**,*** | 1.25 |
| Aripiprazole (30) | 11.20 | 0.90 | 11.89 | 0.96 | 12.32* | 1.30 | 7.25*,** | 0.80 |
| Aripiprazole (3) | 12.63 | 1.39 | 8.57 | 0.96 | 12.14* | 1.71 | 8.27*,** | 2.08 |
| ITI-007 (10) | 8.40 | 0.63 | 6.02 | 0.59 | 10.47 | 2.89 | 5.80 | 2.45 |
| ITI-007 (3) | 7.47 | 0.98 | 4.57 | 0.48 | 7.99 | 1.24 | 4.54 | 0.73 |
| ITI-007 (1) | 8.06 | 1.37 | 4.98 | 0.80 | 9.44 | 4.34 | 4.69 | 0.61 |
*p < 0.05 compared with vehicle alone; **p < 0.05 compared with ITI-007 (3); ***p < 0.05 compared with ITI-007 (10)