Table 4.
Regional effects of ITI-007, clozapine, haloperidol, and imipramine on GSK-3β phosphorylation state (mean ± SEM) in mouse brain
| Phospho-S9 GSK-3β (% vehicle control) | |||||||
|---|---|---|---|---|---|---|---|
| Dose (mg/kg) | ITI-007 | Clozapine | Haloperidol | Imipramine | |||
| 0 | 3 | 10 | 30 | 5 | 1 | 20 | |
| Accumbens | 100 ± 3.0 | 122.9 ± 8.6** | 120.8 ± 3.6*** | 105.5 ± 2.2 | 125.9 ± 10** (100 ± 2.8)a | 99.4 ± 4.2 (100 ± 3.3)a | 108.7 ± 6.2 (100 ± 1.9)a |
| PFC | 100 ± 2.1 | 103.4 ± 3.1 | 126.0 ± 4.9*** | 112.1 ± 2.7* | 140 ± 5.8** (100 ± 4.0)a | 96.2 + 2.6 (100 ± 4.0)a | 92 ± 4.6 (100 ± 5.9)a |
| Striatum | 100 ± 2.9 | 106.6 ± 2.1 | 98.2 ± 5.1 | 108.0 ± 2.9 | 117.5 ± 23.5 (100 ± 3.2)a | 114.7 ± 3.5 (100 ± 3.3)a | 106.4 ± 8.6 (100 ± 3.7)a |
*p < 0.05; **p < 0.01; ***p < 0.001 compared with vehicle (0) ANOVA with Newman–Keuls post hoc test
aControl values ± SEM