Table 2.
Comparative biodistribution of 99mTc-ZIGF1R:4551-GGGC and [99mTc(CO)3]+-(HE)3-ZIGF1R:4551 in mice bearing DU-145 and MCF-7 xenografts at 4 h after injection
| DU-145 | MCF-7 | |||
|---|---|---|---|---|
| 99mTc-ZIGF1R:4551-GGGC | [99mTc(CO)3]+-(HE)3-ZIGF1R:4551 | 99mTc-ZIGF1R:4551-GGGC | [99mTc(CO)3]+-(HE)3-ZIGF1R:4551 | |
| Blood | 0.14 ± 0.01* | 0.47 ± 0.03 | 0.2 ± 0.07* | 0.36 ± 0.04 |
| Lung | 1.19 ± 0.07* | 2.02 ± 0.5 | 1.6 ± 0.3 | 1.6 ± 0.2 |
| Liver | 4.08 ± 0.1* | 3.5 ± 0.4 | 6.07 ± 0.1* | 3.06 ± 0.4 |
| Spleen | 3.0 ± 0.6* | 1.56 ± 0.2 | 3.11 ± 0.7* | 1.43 ± 0.3 |
| Pancreas | 0.98 ± 0.1 | 1.13 ± 0.1 | 1.41 ± 0.2 | 1.1 ± 0.15 |
| Stomach | 1.04 ± 0.3 | 1.38 ± 0.2 | 1.44 ± 0.3 | 1.19 ± 0.2 |
| Colon | 1.5 ± 0.4 | 1.6 ± 0.2 | 1.4 ± 0.1 | 1.55 ± 0.2 |
| Kidney | 7.5 ± 0.7* | 116 ± 7 | 9.5 ± 0.4* | 164 ± 3 |
| Sal gland | 1.6 ± 0.1 | 1.9 ± 0.3 | 1.4 ± 0.2 | 1.2 ± 0.2 |
| Tumor | 0.9 ± 0.1* | 1.3 ± 0.2 | 1.2 ± 0.2 | 1.6 ± 0.3 |
| Muscle | 0.27 ± 0.02 | 0.31 ± 0.06 | 0.29 ± 0.07 | 0.26 ± 0.07 |
| Bone | 0.63 ± 0.1 | 0.61 ± 0.15 | 0.59 ± 0.06 | 0.6 ± 0.1 |
The data are expressed as %IA/g and present the average value from 4 animals ± standard deviation
* Significant difference (p < 0.05) between the uptake of 99mTc-ZIGF1R:4551-GGGC and [99mTc(CO)3]+-(HE)3-ZIGF1R:4551 Affibody molecules in mice bearing DU-145 and MCF-7 xenografts