Fig. 4.

Behavioral tests with spadin and analogs 3 and 8. a FST performed after an acute treatment, immobility times were measured 30 min after the i.v. injection of drugs, 10 μg/kg in a single bolus of 100 μL of NaCl 0.9 %. b FST performed after a subchronic treatment (4 days, 4d); immobility times were measured on the fifth day after a daily i.v. injection of drugs, 10 μg/kg in a single bolus of 100 μL of NaCl 0.9 % for four consecutive days. c NSF performed after a subchronic treatment (4 days, 4d); latencies to feed were measured on the fifth day after a daily i.v. injection of drugs, 10 μg/kg in a single bolus of 100 μL of NaCl 0.9 % for 4 days. d, e LHT performed after a subchronic treatment (4 days, 4d); latencies to feed were measured on the fifth day after a daily i.v. injection of drugs, 10 μg/kg in a single bolus of 100 μL of NaCl 0.9 % for 4 days. d Mean escape latencies for the entire experiment. e The mean escape latencies by blocks of five trials. *p < 0.05, **p < 0.01, ***p < 0.001