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. Author manuscript; available in PMC: 2016 Jan 20.
Published in final edited form as: Immunity. 2014 Dec 25;42(1):186–198. doi: 10.1016/j.immuni.2014.12.021

Figure 6. Variable DREs are enriched for inherited and acquired sequence variants.

Figure 6

A) Percentage of variable and unchanged DREs with either SNPs and SNVs. B) Enrichment or depletion of disease- or trait-associated SNPs in variable DREs. C) Number of SNVs within variable DREs in each FL sample. D) Fraction of sequence variants that disrupt TF motifs in unchanged versus variable DREs. Statistical significance for panels A, B, and D (χ2 test): **** p≤ 0.0001. E) Representative disease-associated SNPs and SNVs predicted to disrupt TF motifs.