Anti-vascular endothelial growth factor for macular edema secondary to central retinal vein occlusion

. Author manuscript; available in PMC: 2015 Jan 22.

Published in final edited form as: Cochrane Database Syst Rev. 2010 Oct 6;(10):CD007325. doi: 10.1002/14651858.CD007325.pub2

Characteristics of excluded studies [ordered by study ID]

Study	Reason for exclusion
Byeon 2009	Randomized controlled trial comparing adjuvant topical treatment with an aqueous depressant (timolol-dorzolamide) twice daily for 9 weeks, to no adjuvant treatment (control), in patients receiving a single injection of 1.25 mg bevacizumab for ME resulting from retinal vein occlusion, with 9-week follow up. Of 19 patients in each arm, only 5 in the adjuvant treatment group and 4 in the control group had CRVO-ME, with the remainder having BRVOME. Subgroup analysis of outcomes in the CRVO-ME group was not reported and the small CRVO-ME subgroup alone had insufficient power to address the null hypothesis of no difference between groups in the elimination of bevacizumab, as estimated by a change in central retinal thickness on OCT, at 1, 5 and 9 weeks follow up.

Study

Reason for exclusion

Byeon 2009

Randomized controlled trial comparing adjuvant topical treatment with an aqueous depressant (timolol-dorzolamide) twice daily for 9 weeks, to no adjuvant treatment (control), in patients receiving a single injection of 1.25 mg bevacizumab for ME resulting from retinal vein occlusion, with 9-week follow up. Of 19 patients in each arm, only 5 in the adjuvant treatment group and 4 in the control group had CRVO-ME, with the remainder having BRVOME. Subgroup analysis of outcomes in the CRVO-ME group was not reported and the small CRVO-ME subgroup alone had insufficient power to address the null hypothesis of no difference between groups in the elimination of bevacizumab, as estimated by a change in central retinal thickness on OCT, at 1, 5 and 9 weeks follow up.

BRVO: branch retinal vein occlusion

CRVO: central retinal vein occlusion

ME: macular edema

mg: milligrams

OCT: ocular coherence tomography