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. Author manuscript; available in PMC: 2015 Jan 22.
Published in final edited form as: Recent Res Dev Virol. 2014;9:1–24.

Figure 6.

Figure 6

Map of the 14 protein isoforms of CD46. A) CD46 mRNA exon map relative to protein domains. LS, leader sequence; SCR, short consensus repeats; STP, serine-threonine-proline repeat domains; TM, transmembrane domain; Cyt, cytoplasmic domain. B) The portions of the exons expressed in each isoform are colored green. Many of the splice forms of CD46 differ only in the last two exons of the cytoplasmic tail region: exons 13 and 14. CD46 isoforms are named for the STP domains, A, B, or C (exons 7, 8, and 9, respectively), and the cytoplasmic tails, Cyt-1 or Cyt-2, that they contain. The isoform BCδCyt-2 contains only part of the transmembrane domain encoded by exon 12. C) Schematic of CD46 showing all domains and the distinct amino acid sequences within the two cytoplasmic domains. Protein isoforms differ in the STP (serine-threonine-proline; A, B, or C) domains and Cyt (cytoplasmic) domains. U, unstructured region with no ascribed function.