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The modulation of CYP and P-gp by green tea.
| Compound type | Species | System | CYP | P-gp | Ref. |
|---|---|---|---|---|---|
| Extract | Rat |
In vivo
Activity |
CYP1A (↑) CYP2B (↑) CYP3A (↑) |
[41–43] | |
|
| |||||
| Extract | Human |
In vitro
Activity |
CYP2C9 (↓) CYP2D6 (↓) CYP3A4 (↓) |
[43] | |
|
| |||||
| Extract | Human |
In vitro
mRNA/protein |
CYP1A1 (↑) CYP1A2 (↑) |
[44] | |
|
| |||||
| EGCG | Human |
In vitro
Activity |
CYP1A2 (↓) CYP3A4 (↓) |
[44] | |
|
| |||||
| Catechins | Human |
In vitro
Activity |
P-gp (↓) | [45] | |
|
| |||||
| EGCG | Human |
In vitro
Activity |
P-gp (↓) | [46] | |
