Table 3. Summary of correlations between CpGs and genes under methylation regulation in previous studies.
| Methylation CpG site | Gene symbol | Correlation | Correlation p-value | CpG islanda | Chromosome | Strand | Dis_TSSb |
|---|---|---|---|---|---|---|---|
| cg14262937 | OPRM1 | -0.329 | 0.000298 | False | Chr6 | + | -92 |
| cg07715387 | SLC1A4 | -0.263 | 0.000967 | True | Chr2 | + | 144 |
| cg10007262 | RELN | -0.213 | 0.004023 | True | Chr7 | − | -1256 |
| cg09722397 | GRIN2C | -0.200 | 0.009505 | True | Chr17 | − | 1023 |
| cg02218260 | GRM2 | -0.197 | 0.046061 | False | Chr3 | + | 1800 |
| cg15926585 | COMT | -0.165 | 0.014661 | False | Chr22 | + | -864 |
| cg19257200 | SOX10 | -0.237 | 0.002032 | False | Chr22 | − | 2446 |
| cg06614002 | SOX10 | -0.232 | 0.013858 | False | Chr22 | − | 2990 |
a
False (CpG island) = CpG site is not in CpG island; True (CpG island) = CpG site is in CpG island.
b
Dis_Tss = distance to the transcription start site. Negative value means that the CpG locates on the promoter region; and positive value means that the CpG locates on the gene body region.