Table 2. Statistical Evaluation of LC-MRM Performance in Separating Patient Groups.

Each immunoglobulin measurement is compared between the population of SPEP positive patients and patients with other diagnoses. For isoform-specific measurements, the diagnosis of the involved immunoglobulin is achieved solely by LC-MRM. In each case, the number of patients as well as the mean, standard deviation, and the median of the protein expression are listed.

Monitored Protein(s)	Corresponding Ig Diagnosis				Other Diagnoses				Statistical Results
	n	Mean	SD	Median	n	Mean	SD	Median	z- value	p- value
IgA1,2	21	14.83	16.53	6.20	62	0.66	0.61	0.46	5.10	3.5E−7
IgA2	21	0.03	0.04	0.01	62	0.08	0.18	0.03	−1.36	0.17
IgG1,2,3	21	16.59	18.57	12.40	62	4.26	3.06	3.78	4.92	8.8E−7
IgG1	10	15.19	5.38	13.74	73	2.40	1.91	1.81	5.09	3.7E−7
IgG3	4	30.95	41.11	17.62	79	0.66	0.60	0.53	2.24	0.02
IgM	18	7.26	9.05	3.69	65	0.10	0.10	0.06	6.45	1.4E−10
κ LC	36	11.99	11.09	8.83	47	2.37	1.72	2.04	6.16	7.2E−10
λ LC	36	12.00	30.00	1.75	47	0.44	0.63	0.22	5.66	1.6E−8
IgD	5	6.57	8.37	2.30	78	0.00	0.03	0.00	7.23	4.8E−13

Statistical significance was assessed by the Holm-Bonferroni method; z-values and p-values are listed.