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. 2015 Jan 9;12:222. doi: 10.1186/s12974-014-0222-3

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© Yan et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Presynaptic mechanisms contribute to the lipopolysaccharide (LPS)-induced suppression of GABAergic synaptic activities. Shown is the GABAergic miniature inhibitory postsynaptic currents (mIPSCs) recorded with a recording pipette filled with the intracellular solution containing the protein kinase C (PKC) inhibitor (PKCI 19–30, 5 μM) at baseline, during and after washout of LPS (1 μg/ml). Bar graphs show mean (+SE) amplitudes and frequency before, during and after washout of LPS. Number of neurons included in each group for the analysis is shown in each bar. *P < 0.05; **P < 0.01; ***P < 0.001.