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. 2015 Jan 9;12:222. doi: 10.1186/s12974-014-0222-3

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© Yan et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inhibition of protein kinase C (PKC) or IL-1β receptors blocks the inhibitory effects induced by lipopolysaccharide (LPS) on GABAergic synaptic activities at the presynaptic site. A sample of GABAergic miniature inhibitory postsynaptic currents (mIPSCs) recorded in the presence of the IL-1β receptor blocker (IL-1ra, 100 ng/ml) (A) or PKC inhibitor (GF109203X, GF) (B) before, during, and after washout of LPS (1 μg/ml). Bar graphs show that mean (+SE) frequencies and amplitudes of GABAergic mIPSCs before (baseline), during perfusion of IL-1ra or GF109203X and further addition of LPS in the presence of IL-1ra (C) or GF109203X (D). NS: no statistical significance.