Table 6.
Single gene effects confirmed for ATPalpha alleles using RNAi
| Cytological region | Gene | Putative function # | ATPα Allele | Nature of interaction | Significance |
|---|---|---|---|---|---|
| 21A1-21B1 | Galectin | Galactoside binding [45] | CJ10 | Suppressor | ** |
| 21A1-21B1 | Galectin | “ | CJ5 | Suppressor | *** |
| 22 F4-22 F4 | CG3528 | Unknown | DTS1 | Enhancer | * |
| 22 F4-22 F4 | CG3528 | CJ10 | Suppressor | * | |
| 22 F4-22 F4 | CG3528 | CJ5 | Suppressor | * | |
| 27E-28B1 | Ndae1 | Na + driven anion exchanger [47] | CJ5 | Enhancer | * |
| 29B4-29E4 | Glt | Cell surface glycoprotein [50] | CJ10 | Suppressor | * |
| 30C8-30C9 | Ppk11 | Sodium channel [52] | CJ5 | Suppressor | ** |
| 31C-32E | FKBP59 | Calcium channel regulator [53] | CJ5 | Suppressor | *** |
| 31C-32E | FKBP59 | “ | DTS1 | Enhancer | * |
| 33A1-33A1 | Vha100-5 | ATPase, proton transport | DTS1 | Enhancer | * |
| 33A2-33A2 | Esc | Histone methyltransferase component [74] | DTS1 | Enhancer | *** |
| 33A2-33A2 | Esc | “ | CJ10 | Suppressor | ** |
| 34E4-35B4 | Dyrk2 | Serine/Threonine kinase [55] | DTS1 | Enhancer | * |
| 34E4-35B4 | Dyrk2 | “ | CJ5 | Suppressor | *** |
| 37A2-37A4 | Ham | Transcription factor [75] | DTS1 | Suppressor | * |
| 37A2-37A4 | Ham | “ | CJ5 | Suppressor | ** |
| 37C1-37C1 | Ddc | Amino acid decarboxylase [76] | CJ5 | Suppressor | *** |
| 25 F1-36A1 | CG5888 | Toll 3 like Receptor | CJ10 | Suppressor | ** |
| 25 F1-36A1 | CG5888 | “ | CJ5 | Suppressor | * |
| 50C5-50C6 | Stj | Voltage-gated calcium channel regulatory subunit [77,78] | DTS1 | Enhancer | **** |
| 50C5-50C6 | Stj | “ | CJ5 | Enhancer | ** |
| 51D1-51D1 | Cyp6a19 | Cytochrome P450 | CJ10 | Suppressor | * |
| 62E8-63B6 | Spz5 | Neurotrophin [61,62] | DTS1 | Suppressor | ** |
| 62E8-63B6 | Spz5 | “ | CJ10 | Suppressor | * |
| 62E8-63B6 | Rasp | Palmitoyl transferase [65,66] | CJ5 | Suppressor | *** |
| 63A3-63A3 | FMRFaR | Neuropeptide receptor [79] | DTS1 | Enhancer | ** |
| 63A3-63A3 | FMRFaR | “ | CJ10 | Suppressor | ** |
| 63A3-63A3 | FMRFaR | “ | CJ5 | Suppressor | **** |
| 64C2-64C5 | Con | Homophilic cell adhesion [80] | DTS1 | Suppressor | * |
| 64C2-64C5 | Con | “ | CJ5 | Suppressor | ** |
| 67A2-67D13 | Aay | Predicted phosphoserine phosphatase | CJ10 | Suppressor | * |
| 67A2-67D13 | Aay | “ | CJ5 | Suppressor | ** |
| 67B9-67B9 | Uch-L5 | 26S Proteasome component [81] | DTS1 | Enhancer | * |
| 67D11-67D11 | Scramb1 | Phosphatidyl serine scramblase | CJ10 | Suppressor | ** |
| 99B5-99B6 | Dop1R2 | Dopamine 1-like receptor [82,83] | CJ5 | Suppressor | *** |
| 99B6-99B6 | Ppk21 | Sodium channel | DTS1 | Suppressor | ** |
| 99B6-99B6 | Ppk21 | “ | CJ10 | Suppressor | * |
| 100B9-100B9 | Ppk24 | Sodium channel | DTS1 | Suppressor | ** |
| 100B9-100B9 | Ppk24 | “ | CJ5 | Suppressor | * |
| 100B9-100B9 | Ppk24 | “ | CJ10 | Suppressor | ** |
| 100C1-100C1 | CG11340 | Predicted chloride channel | DTS1 | Suppressor | * |
| 100C1-100C1 | CG11340 | “ | CJ5 | Suppressor | *** |
| 100C1-100C1 | CG11340 | “ | CJ10 | Suppressor | * |
Many genes had an interaction with more than one allele, although some appear to be allele specific. RNAi knockdowns were compared with ATPalpha*, daGal4/+ controls. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
#Function per flybase.org and/or listed citation.