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. 2015 Jan 17;3:2. doi: 10.1186/s40478-015-0183-5

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© Wegiel et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Increase of neuronal nuclei volume in teenagers and adults with autism, and decrease in control cohort. Estimates of nucleus volume (μm³) in three age groups of subjects with autism revealed significant increase in eight brain regions (white arrows). In the control cohort, the volume of neurons decreased significantly in 14 regions. The significance level was computed by controlling for post-mortem interval, days of fixation, days of dehydration, and brain weight loss during dehydration. Large arrows indicate a significant difference in both age groups; small arrow marks a significant difference in one of two age groups.