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. 2014 Dec 24;9:217. doi: 10.1186/s13023-014-0217-2

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© Quijada-Fraile et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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(Case 8): MRI coronal T2W. Abnormal high signal sparing the subcortical white matter with slightly periventricular location before folinic acid treatment were detected (A), improving after 2 years of folinic acid treatment (B). Abnormal high signal in the parietal white matter in MRI axial T2W was also observed before folinic acid treatment (C). Decreased of high signal after 2 years of treatment with near normal white matter signal (D).