Table 2.
Biochemical data and folinic acid therapy in KSS patients
| Case | Age at the start of folinic acid treatment (years) | Folinic acid doses (mg/kg/day) | Time of therapy between lumbar puncture (years) | Plasma folate (ng/ml) NV: 2.6-18.7 | Plasma lactate (mmol/L) NV:0.5-2.3 | CSF values before and after therapy | ||
|---|---|---|---|---|---|---|---|---|
| 5-MTHF (nmol/L) NV: 35-124 | Lactate (mmol/L) NV: <2.8 | Protein (mg/dl) NV: 15-41 | ||||||
| 1 | 8.5 | 1 | 0.8 | 25 | 3 | 7➔48 | 5.1/- | 115/- |
| 2 | 11 | 1 | 3.7 | - | 1.5 | 5.6➔60 | 2.1➔1.4 | 121➔142 |
| 3 | 17 | 1 | - | 20 | 1.4 | 2 | 3.5 | 165 |
| 4 | 14 | 1 | - | - | 2.5 | 6 | 5.7 | 169 |
| 5 | - | - | - | 5.3 | 2.3 | 24 | 5.9 | 80 |
| 6 | 13 | 3 | - | - | - | 4 | 4.2 | 160 |
| 7 | - | - | - | 9.9 | 3.5 | 1 | 3.5 | 244 |
| 8 | 8 | 3 | 1 | 1.2 | 2.5 | 8➔82 | 5.2➔1.2 | 89➔117 |
CSF (cerebrospinal fluid), NV (normal values).