Table 1.
Characteristics of 200 patients by HPV status
| Patient or tumor characteristics | HPV-positive (%) | HPV-negative (%) | P-value | Control (%) |
|---|---|---|---|---|
| No. of cases | 42 (21) | 158 (79) | – | 10 |
| Age | ||||
| Average (range) | 58.2 (35–80) | 59.8 (40–88) | 0.341 | 59.2 (27–93) |
| Sex | ||||
| Male | 33 (79) | 106 (67) | 0.151 | 6 (60) |
| Female | 9 (21) | 52 (33) | 4 (40) | |
| Smoking history | ||||
| Never | 14 (33) | 8 (5) | <0.001 | 3 (30) |
| Former | 21 (50) | 128 (81) | 1 (10) | |
| Active smoker | 7 (17) | 22 (14) | 5 (50) | |
| Alcohol use | ||||
| Never | 12 (28.6) | 13 (8.2) | <0.001 | 4 (40) |
| Former | 0 (0) | 16 (10.1) | 2 (20) | |
| <2 units/day | 10 (23.8) | 18 (11.4) | 1 (10) | |
| 2–6 units/day | 17 (40.5) | 76 (48.1) | 2 (20) | |
| >6 units/day | 3 (7.1) | 35 (22.2) | 0 (0) | |
| Overall AJCC stage | ||||
| Stage I–II | 4 (9.5) | 22 (14) | 0.451 | – |
| Stage III–IV | 38 (90.5) | 136 (86) | ||
| AJCC tumor size1 | ||||
| T1–2 | 21 (50) | 52 (33) | 0.047 | – |
| T3–4 | 20 (48) | 106 (67) | ||
| AJCC nodal stage2 | ||||
| N0 | 4 (9.5) | 45 (28.5) | 0.017 | – |
| N1–3 | 38 (90.5) | 110 (69.6) | ||
| Treatment | ||||
| RT | 13 (31) | 54 (34) | 0.776 | – |
| RT/chemotherapy | 19 (45) | 74 (47) | ||
| S/S + RT/S + RT + chemotherapy | 10 (24) | 30 (19) | ||
| Second primary tumors | ||||
| Negative | 41 (98) | 138 (87) | 0.084 | – |
| Positive | 1 (2) | 20 (13) | ||
HPV, human papillomavirus; RT, radiotherapy; S, surgery; AJCC, American Joint Committee on cancer.
1
One missing;
2
three missing values.