Table 2.
Body mass index, smoking and alcohol intake, and risk of head and neck squamous cell carcinoma overall and stratified by HPV serology.
| Total | High-risk HPV seropositive | High-risk HPV seronegative | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Cases | Control | OR (95%CI)a | P trend | Cases | OR (95%CI)b | P trend | Cases | OR (95%CI)b | P trend |
| BMI | ||||||||||
| 18.5-25 | 325 | 360 | 1[reference] | 0.08 | 154 | 1[reference] | 0.46 | 119 | 1[reference] | <0.0001 |
| 25-30 | 421 | 504 | 1.01 (0.79, 1.29) | 240 | 1.15(0.88,1.49) | 124 | 0.78(0.57,1.08) | |||
| ≥30 | 213 | 344 | 0.79 (0.60, 1.04) | 131 | 0.91(0.68,1.21) | 53 | 0.48(0.32,0.70) | |||
| Smoking Status | ||||||||||
| Never smoke | 236 | 486 | 1[reference] | 158 | 1[reference] | 52 | 1[reference] | |||
| Ever smoke | 723 | 722 | 1.32(1.01, 1.73) | 367 | 1.23(0.93,1.61) | 242 | 1.62(1.09,2.41) | |||
| Pack-years of smoking per 10 units | 959 | 1108 | 1.10(1.05, 1.16) | 525 | 1.05(1.00,1.10) | 294 | 1.15(1.09,1.21) | |||
| Alcohol | ||||||||||
| First quartile | 173 | 302 | 1[reference] | <0.0001 | 98 | 1[reference] | <0.0001 | 51 | 1[reference] | <0.0001 |
| Second quartile | 152 | 300 | 0.78(0.56, 1.07) | 86 | 0.82(0.58,1.17) | 43 | 0.84(0.53,1.32) | |||
| Third quartile | 189 | 302 | 1.03 (0.75, 1.42) | 121 | 1.16(0.83,1.61) | 46 | 0.87(0.55,1.39) | |||
| Forth quartile | 442 | 301 | 2.10 (1.54, 2.86) | 219 | 1.91(1.38,2.64) | 154 | 2.31(1.53,3.50) | |||
a
model includes HPV status, age, sex, race, education, smoking status, pack-years of smoking per 10 units, alcohol use
b
model includes age, BMI, sex, race, education, smoking status, pack-years of smoking, alcohol use