Table 3. Differentially expressed Ion Channels.
Ion Channel genes whose expression is altered by adolescent ethanol binge-drinking (FDR< 0.05)
| GENE | Fold Change | Gene Name |
|---|---|---|
| Potassium channels | 34 of 67 identified | |
|
| ||
| Kcna1 | 1.35 | potassium voltage-gated channel, shaker-related subfamily, member |
| Kcna3 | −1.48 | potassium voltage-gated channel, shaker-related subfamily, member 3 |
| Kcna4 | −1.41 | potassium voltage-gated channel, shaker-related subfamily, member 4 |
| Kcna6 | −1.35 | potassium voltage-gated channel, shaker-related subfamily, member 6 |
| Kcnab1 | 1.42 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 |
| Kcnab3 | 1.4 | potassium voltage-gated channel, shaker-related subfamily, beta member 3 |
| Kcnc1 | 1.51 | potassium voltage-gated channel, Shaw-related subfamily, member 1 |
| Kcnc2 | −1.24 | potassium voltage-gated channel, Shaw-related subfamily, member 2 |
| Kcnc3 | 3.08 | potassium voltage-gated channel, Shaw-related subfamily, member 3 |
| Kcnd2 | 1.63 | potassium voltage-gated channel, Shal-related subfamily, member 2 |
| Kcng1 | 1.79 | potassium voltage-gated channel, subfamily G, member 1 |
| Kcng4 | 2.15 | potassium voltage-gated channel, subfamily G, member 4 |
| Kcnh1 | 2.24 | potassium voltage-gated channel, subfamily H (eag-related), member 1 |
| Kcnh3 | 4.54 | potassium voltage-gated channel, subfamily H (eag-related), member 3 |
| Kcnh5 | −1.4 | potassium voltage-gated channel, subfamily H (eag-related), member 5 |
| Kcnj12 | 2.64 | potassium inwardly-rectifying channel, subfamily J, member 12 |
| Kcnj3 | 1.7 | potassium inwardly-rectifying channel, subfamily J, member 3 |
| Kcnj6 | 1.31 | potassium inwardly-rectifying channel, subfamily J, member 6 |
| Kcnk1 | 1.51 | potassium channel, subfamily K, member 1 |
| Kcnk10 | 1.35 | potassium channel, subfamily K, member 10 |
| Kcnk12 | 3.06 | potassium channel, subfamily K, member 12 |
| Kcnk16 | 2.64 | potassium channel, subfamily K, member 16 |
| Kcnk2 | −1.51 | potassium channel, subfamily K, member 2 |
| Kcnk3 | 1.6 | potassium channel, subfamily K, member 3 |
| Kcnk9 | −1.6 | potassium channel, subfamily K, member 9 |
| Kcnmb4 | 1.44 | potassium large conductance calcium-activated channel, subfamily M, beta member 4 |
| Kcnn3 | −1.73 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 |
| Kcnq3 | −1.39 | potassium voltage-gated channel, KQT-like subfamily, member 3 |
| Kcns3 | −1.47 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 |
| Kcnt1 | 1.74 | potassium channel, subfamily T, member 1 |
| Kcnt2 | −1.61 | potassium channel, subfamily T, member 2 |
| Kcnv1 | 1.88 | potassium channel, subfamily V, member 1 |
|
| ||
| Sodium Channels | 9 of 14 identified | |
|
| ||
| Scn1b | 2.08 | sodium channel, voltage-gated, type I, beta subunit |
| Scn3a | −1.46 | sodium channel, voltage-gated, type III, alpha subunit |
| Scn3b | −1.63 | sodium channel, voltage-gated, type III, beta subunit |
| Scn4a | −1.67 | sodium channel, voltage-gated, type IV, alpha subunit |
| Scn4b | 1.9 | sodium channel, voltage-gated, type IV, beta subunit |
| Scn5a | −1.63 | sodium channel, voltage-gated, type V, alpha subunit |
| Scn8a | 1.22 | sodium channel, voltage gated, type VIII, alpha subunit |
| Scn9a | −1.91 | sodium channel, voltage-gated, type IX, alpha subunit |
| Scnn1a | −1.45 | sodium channel, non-voltage-gated 1 alpha subunit |
|
| ||
| Calcium Channels | 12 of 21 identified | |
|
| ||
| Cacna1a | 1.53 | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit/ |
| Cacna1b | −1.25 | calcium channel, voltage-dependent, N type, alpha 1B subunit |
| Cacna1d | 1.22 | calcium channel, voltage-dependent, L type, alpha 1D subu |
| Cacna1g | 1.76 | calcium channel, voltage-dependent, T type, alpha 1G subunit |
| Cacna1h | −1.39 | calcium channel, voltage-dependent, T type, alpha 1H subu |
| Cacna1i | 1.49 | calcium channel, voltage-dependent, T type, alpha 1I subunit |
| Cacna2d1 | −1.47 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 |
| Cacnb1 | −1.26 | calcium channel, voltage-dependent, beta 1 subunit |
| Cacnb4 | 1.69 | calcium channel, voltage-dependent, beta 4 subunit |
| Cacng3 | −1.78 | calcium channel, voltage-dependent, gamma subunit 3 |
| Cacng7 | 1.25 | calcium channel, voltage-dependent, gamma subunit 7 |
| Cacng8 | −1.39 | calcium channel, voltage-dependent, gamma subunit 8 |
|
| ||
| Chloride Channels | 6 of 14 identified | |
|
| ||
| Clcn5 | −1.55 | chloride channel, voltage-sensitive 5 |
| Clcn6 | −1.32 | chloride channel, voltage-sensitive 6 |
| Clcnkb | −2.46 | chloride channel, voltage-sensitive Kb |
| Clic1 | 1.61 | chloride intracellular channel 1 |
| Clic2 | −1.43 | chloride intracellular channel 2 |
| Clic6 | 2.93 | chloride intracellular channel 6 |