Figure 2.
Urinary protein (A) and albumin (B) excretion levels relative to urinary creatinine as indices of renal injury in streptozotocin-induced diabetic mice. Protein and albumin excretions increased significantly in diabetic than control mice (*P <0.05 vs. control mice). Inhibition of adenosine kinase with ABT702 treatment resulted in significant reduction in these parameters in diabetic mice (#P <0.05 vs. diabetic mice; n= 7–8/group). However, albuminuria in ABT702 treated diabetic mice remained significantly higher than control non-diabetic mice.