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. 2015 Jan 22;6:2. doi: 10.3389/fphys.2015.00002

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Copyright © 2015 Danastas, Combes, Lindsay, Grau, Thompson and Murphy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signaling pathways of VEGFR-2. The binding of VEGF to VEGFR-2 results in the activation of several intracellular molecules to induce cell survival, increase vascular permeability, cellular migration and proliferation.