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. 2014 Nov 15;141(22):4395–4405. doi: 10.1242/dev.110437

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Mutations in Rac GTPases, UNC-73, UNC-44 and UNC-33 cause increased growth cone filopodial protrusion. (A) The average VD growth cone filopodial duration in different mutant backgrounds in early L2 juIs76 animals. More than 50 filopodia per genotype were scored. (B) Maximal filopodial length in different mutants as described in A. (C) A time-lapse series of a wild-type VD growth cone in early L2. Numbers indicate minutes after imaging began. (D) An unc-44(e362) mutant growth cone showing increased protrusion in the form of longer and more persistent filopodia. Dorsal is up, and anterior is left. Scale bar: 5 µm. (E) Average filopodial length in different genotypes. At least 15 filopodia were scored from at least 15 different growth cones. M+ indicates that the animals had wild-type maternal ced-10(+) activity. (A,B,E) Error bars represent s.e.m. Two-sided t-tests with unequal variance were used to determine statistical significance.