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. 2014 Nov 15;141(22):4395–4405. doi: 10.1242/dev.110437

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — UNC-33 and UNC-44, but not UNC-73, are required for constitutively active MIG-2 and CED-10 filopodial inhibition. (A,B) Quantification of filopodia dynamics in VD growth cones as described in Fig. 2A. Error bars represent s.e.m. Two-sided t-tests with unequal variance were used to determine statistical significance. NS, not significant. (C,D) Time-lapse series of live growth cones (arrowheads) in early L2 animals, taken at 2 min per frame. Dorsal is up, and anterior is left. The unc-73(rh40); mig-2(G16V) growth cone resembled that of mig-2(G16V) alone and did not exhibit the excess protrusion seen in unc-73(rh40) mutants. Scale bar: 5 µm.