Fig. 7.

The migration of endocardial-derived ventral coronary vessels does not require VEGFC. (A) Ventral coronary vessels (DACH1⁺, red) corresponding to endocardial-derived regions of the vasculature are normal in Vegfc knockout (ko) hearts (arrows), as compared with wild type. By contrast, few coronary vessels are in areas that arise from the SV (arrowheads). (B) The area occupied by ventral intramyocardial coronary vessels is not significantly different (ns) between wild-type and Vegfc knockout embryos. (C) Subepicardial vessels (arrowheads) are present in wild-type but not in Vegfc knockout myocardium as shown in optical sections through the ventrolateral region of the heart. Intramyocardial vessels (arrows) are present in both genotypes. Scale bars: 100 µm in A; 25 µm in C.