Table 2.
Plasmodium proteomic datasets.
| Species/Strain | Parasite material | Method | Description | Reference |
|---|---|---|---|---|
| P. falciparum 3D7 | Infected erythrocytes and gametocytes | MudPIT* | P. falciparum asexual blood stage and sexual stage proteomes. 2,415 parasite proteins identified. | Florens et al. (2002) |
| P. falciparum NF54 | Trophozoites, schizonts, gametocytes, and gamete | LC-MS/MS** | P. falciparum asexual blood stage and sexual stage proteomes. 1,289 proteins detected: 714 in asexual blood stages, 931 in gametocytes and 645 in gametes. | Lasonder et al. (2002) |
| P. falciparum 3D7 | Infected erythrocytes | MudPIT | P. falciparum parasite infected erythrocyte surface proteome. 423 proteins identified. | Florens et al. (2004) |
| P. falciparum 3D7 | Infected erythrocytes | MudPIT | P. falciparum infected erythrocyte proteome. 802 proteins identified in the nuclear proteome. | Oehring et al. (2012) |
| P. falciparum 3D7 and P. vivax Sal-1 | Infected erythrocytes | LC-MS/MS | Proteomic analyses of clinical isolates of early stages of P. falciparum and P. vivax. 100 proteins identified. | Acharya et al. (2009) |
| P. falciparum 3D7, F12 | Trophozoites, gametocytes | LC-MS/MS | Quantitative comparative proteomics analysis of trophozoites and early gametocyte stages of P. falciparum. 1090 new proteins identified. | Silvestrini et al. (2010) |
| P. vivax Sal-1 | Infected erythrocytes | MS/MS† | Elucidation of the P. vivax schizont proteome from clinical sample. 316 proteins identified. | Roobsoong et al. (2011) |
| P. falciparum 3D7 and P. berghei ANKA | Midgut and salivary glands Sporozoites | nLC-MS/MS | Proteomic comparison of sporozoites from oocysts and salivary glands. 127 proteins identified in oocysts, 450 in oocyst-derived sporozoites, and 477 in salivary gland sporozoites. | Lasonder et al. (2008) |
| P. falciparum 3D7 and P. yoelii 17XNL | Salivary gland sporozoites | LTQ Orbitrap Velos§, nLC-MS/MSi | Putative surface proteomes of P. falciparum and P. yoelii salivary gland sporozoites. 1991 P. falciparum sporozoite proteins and 1876 P. yoelii sporozoite proteins identified. | Lindner et al. (2013) |
| P. berghei ANKA | Mixed asexual blood stages, gametocytes, ookinetes, oocysts and salivary gland sporozoites | MudPIT | P. berghei oocysts and sporozoite proteomes. 1836 proteins identified: 1139 in blood stage, 1091 in ookinetes, 733 in gametocytes, 277 in oocysts and 134 in salivary gland sporozoites. | Hall et al. (2005) |
| P. berghei ANKA | Gametocytes | LC-MS/MS | Comparative proteomic analysis of male vs female gametocytes. 353 proteins in mixed-gametocyte proteome identified, 305 proteins in male gametocytes, and 170 proteins in female gametocytes. | Khan et al. (2005) |
| P. yoelii 17X | Infected hepatocytes | LC-MS/MS | P. yoelii liver stage proteome. 712 proteins identified. | Tarun et al. (2008) |
*MudPIT, Multidimensional protein identification technology; ∗∗LC-MS/MS, liquid chromatography tandem mass spectrometry; nLC-MS/M S, nano flow liquid chromatography mass spectrometry; †MS/MS, tandem mass spectrometry; §LTQ Orbitrap Velos, TQ Orbitrap Velos mass analyzer coupled to nano-liquid chromatography.