Table 4.
Plasmodium antigens identified from genome-based datasets.
| Antigen | Model | Main finding | Reference |
|---|---|---|---|
| Ag2/CelTOS | P. falciparum RAS T cell screening;P. yoelii and P. berghei murine immunization/challenge | One of four highly reactive P. falciparum proteins identified by T cell based screening of 27 putative proteins with RAS immunized volunteers; conferred cross-species protection against P. yoelii and P. berghei sporozoite challenge. | Doolan (in preparation), Doolan et al. (2003); Bergmann-Leitner et al. (2010) |
| Thirty-four pre-erythrocytic antigens | P. yoelii murine immunization/challenge | Only three antigens (P33p[Py52] [PY01340], Ag2 [PyCelTOS], and Ag5[PY00419] elicited CD8+ T cell responses but none conferred protection. | Mishra et al. (2011) |
| PY03011, PY03424, and PY03661: pre-erythrocytic antigens | P. yoelii murine immunization/challenge | The combination of the three antigens (but not individual antigens) conferred sterile protection against P. yoelii sporozoite challenge in a high proportion of mice. | Limbach et al. (2011) |
| PyTmp21(PY06414): pre-erythrocytic antigen | P. yoelii murine immunization/challenge | PyTmp21 elicited functional immunity that significantly reduced liver stage parasite burden following P. yoelii sporozoite challenge. | Chen et al. (2014) |
| PbS20 and PbTRAP pre-erythrocytic antigens | P. berghei murine immunization/challenge | Systematically evaluated H(2b)-restricted peptides predicted from genome-wide analysis, and identified two epitopes as targets of CD8+ T cells induced by whole parasite vaccines; CD8+ T cells specific for the PbTRAP epitope but not the PbS20 epitope inhibited liver stage parasite development in vivo | Hafalla et al. (2013) |
| PyTAM: blood-stage antigen | P. yoelii murine immunization/challenge | PyTAM elicited functional immunity that conferred significant protection against mortality from lethal P. yoelii challenge infection. | Cherif et al. (2014) |
| Py01157: sexual and sexual stage antigen | P. yoelii murine immunization/challenge | Py01157: conferred partial protection against challenge with non-lethal P. yoelii 17XNL, but not against challenge with lethal P. yoelii 17XL. | Zhang et al. (2012) |