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. 2015 Jan 21;6:6121. doi: 10.1038/ncomms7121

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(a) Schematic drawing of targeting strategy. Exons 4, 5 and 6 were flanked with two loxP sites. (b) PCR genotyping revealed Gpr56^fl/fl, Gpr56^+/+ and Gpr56^fl/+ alleles. (c) Western blot analysis shows absence of GPR56 protein in Gpr56^fl/fl;EIIA-Cre^+/−. (d) ISH of Plp (red) in the CC of P21 Gpr56^fl/fl;Pdgfrα-Cre^+/− mice (lower panel) and Gpr56^fl/+;Pdgfrα-Cre^−/− controls (upper panel) that received tamoxifen for five consecutive days during P10-P14. Scale bar, 100μm. (e) Quantification of Plp⁺ mature OLs. The asterisks represent significance based on unpaired t-test. P=0.0177; unpaired t-test, n=4 per genotype. Error bars are means ±s.e.m.