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. 2015 Jan 21;6:6121. doi: 10.1038/ncomms7121

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(a) GPR56 is mainly expressed in NG2⁺/PDGFRα⁺ OPCs. Its expression is downregulated beginning at the immature O4⁺ OL stage. The shaded area depicts the developmental stages where GPR56 expression is detected. (b) Model of GPR56 function in OPCs. GPR56, on binding to its unknown ligand, promotes OPC proliferation by activating RhoA.