Table 1.

Tumors develop a complex network of cellular interactions involving both proinflammatory and suppressive cells.

Immunosuppressive	Proinflammatory
C5a/C5aR → MDSC recruitment	C5a attract CD8+ T-cells
AMP involved in angiogenesis	AMP exert cytotoxic activity
↓Expression of human β defensin 1 → tumor progression (prostate cancer)	↑ hBD3 associate with recruitment TAM (lung cancer, renal cell carcinoma, and OSCC)
HPN1 inhibition Classical and Lectin pathway	β defensins bind to a variety of receptors (CCR2)
Express α defensins (HPN1-3) in endothelial → angiogenesis	hBD1 bind to CCR6 resulting in ↑ CD4+
Express α defensins (HPN1-3) in endothelial → angiogenesis	Blockage of C5aR ↓ decrease tumor growth
Deficiency of LL37aid in inflammation and tumor progression	Overexpression hBD3 → chemoattract monocytes tumor microenvironment
	↑ ↑ ↑ HPN1-3 → cytotoxic effect on cancer cell line