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Suppression of cross-reacting anticapsid antibodies by anti-CD4. GAA-KO mice were injected with AAV2/9-CBhGAApA (+) anti-CD4 (3 times; n=6) or without (−) anti-CD4 (n=6) pretreatment. Blood was sampled for ELISA quantification of anti-AAV9 or anti-AAV8 IgG at week 12. Following the injection of AAV2/8-LSPGFPpA at week 20, blood was sampled again at week 24. (A) Anti-AAV9. (B) Anti-AAV8. (C) Anti-AAV9 at week 24. (D) Anti-AAV8 at week 24. *p<0.05; ***p<0.001.
