FIG. 2.

Intra-neurospheral hDPSCs are characterized by an increased metabolic activity and intercellular communication. Intra-neurospheral hDPSCs were characterized by a prominent nucleolus [(A), asterisk], rough endoplasmatic reticulum [(B), asterisk], and Golgi apparatus [(B), arrow] indicating an increased metabolic activity. Cell integrity was lost in a subset of neurospheral cells [(A), arrowheads]. Intercellular communication was increased, as shown by coated pits and vesicle uptake [(C), arrowhead and circle] in addition to the presence of electron-dense vesicles in the cytoplasm of intra-neurospheral cells [(D), asterisk]. Extracellular matrix deposition was observed between cells [(D), arrowhead, details in insert]. Scale bars: (A)=5 μm; (B)=2 μm; (C, D)=1 μm.