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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Neurobiol Aging. 2014 Aug 27;36(0 1):S194–S202. doi: 10.1016/j.neurobiolaging.2014.05.036

Figure 2. (Brain Location #2).

Figure 2

(Top panel) Whole brain 3D maps show areas where regional brain volumes correlated significantly with BMI after controlling for site, age, sex, race, educational level, and diagnosis, plus PA (N = 963; FDR q = 0.05, critical uncorrected P = 0.0398). (Middle panel) Maps show brain regions significantly associated with diagnosis (AD/MCI v. Controls) after correcting for the same effects, plus BMI (N = 963; FDR q = 0.05, critical uncorrected P = 0.0047). Beta maps were significant after standard correction for multiple comparisons and represent the estimated degree of tissue excess or deficit at each voxel, as a percentage, for each unit gain in BMI and/or positive diagnosis (AD/MCI). (Lower panel) 3D maps show regions of significant brain volume differences from both higher BMI and the positive diagnosis (AD/MCI) using a conjunction analysis displayed over a study-specific template. P maps are corrected for multiple comparisons on the basis of FDR (FDR q-level = 0.05, critical uncorrected P = 0.0008). The same slices are shown in each panel and images are displayed in radiological convention (left side of the brain shown on the right).