Table 3.

Revision of heritability for traits in the Framingham Heart Study family data

Traits	Kinship only	Significant variance componentsa				$\mathit{\Delta }{h}_{\mathrm{A}}^2(\%)$	Source of effectb	LR, df (p value)b
	${\widehat{h}}_{\mathrm{A}}^2$	${\widehat{h}}_{\mathrm{A}}^2$	${\widehat{\sigma }}_{\text{SP}}^2$	${\widehat{\sigma }}_{\mathrm{U}}^2$	${\widehat{\sigma }}_{\mathrm{M}}^2$
Anthropometric
Height	0.82	0.84	0.13	0	0.03	−2	SP + M	171, 2, <0.0001
Weight	0.43	0.46	0.16	0	0	−6	SP	51, 1, <0.0001
Body mass index	0.44	0.46	0.14	0	0	−4	SP	38, 1, <0.0001
Metabolic
Systolic blood pressure	0.40	0.39	0.06	0.06	0	3	SP + U	36, 2, <0.0001
Diastolic blood pressure	0.33	0.32	0.06	0.05	0	3	SP + U	30, 2, <0.0001
Fasting blood glucose	0.33	0.29	0	0.06	0	14	U	12, 1, 0.005
Fasting blood insulin	0.26	0.22	0	0.05	0	18	U	7, 1, 0.006
Total cholesterol	0.49	0.45	0	0	0.03	9	M	5, 1, 0.025
HDL cholesterol	0.46	0.44	0	0.04	0	5	U	8, 1, 0.005
LDL cholesterol	0.49	0.44	0	0	0.04	11	M	6, 1, 0.014
Triglyceride	0.41	0.39	0.06	0.05	0	5	SP + U	20, 2, <0.0001
Life style
Alcohol consumption	0.25	0.22	0.36	0.06	0	14	SP + U	101, 2, <0.0001
Protein intake	0.17	0.12	0	0.05	0	42	U	3, 1, 0.08
Fat intake	0.22	0.15	0.27	0	0.05	47	SP + M	16, 2, 0.0003
Carbohydrate intake	0.27	0.28	0.35	0	0	−4	SP	20, 1, <0.0001

^a ${\widehat{\sigma }}_{\mathrm{R}}^2$, estimated variance components. R stands for spousal correlation (SP), sibling effect (U), maternal inheritance (M)

^bDetailed information on the estimates of all variance components using the nine models, likelihood ratio (LR) tests (with degree of freedom, df) between the models with additional component (s) and the model with only familial correlation are demonstrated in Supplementary Table 5 and Fig. 3