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. Author manuscript; available in PMC: 2015 Jan 22.
Published in final edited form as: Biochem J. 2009 Jun 12;421(1):1–15. doi: 10.1042/BJ20081016

Figure 7. Working model of Akt/14-3-3/PP2A regulation of PACS-2 apoptotic activity.

Figure 7

Under non-stressed conditions, apoptotic PACS-2 is phosphorylated on Ser437 and held inactive in the cytosol through binding to 14-3-3 isoforms. Loss of Akt signalling or apoptotic activation of PP2A leads to dephosphorylation of PACS-2 and release from 14-3-3. ‘Activated’ PACS-2 binds and facilitates translocation of full-length Bid to mitochondria, inducing cytochrome c release. This pathway parallels the previously described 14-3-3-regulated translocation of the pro-apoptotic protein Bad [182,183].