Table 1.

Potential Antibody Targets to Block Cell-Associated Human Immunodeficiency Virus (HIV) Transmission

Target Class	Specific Targets (Antibodies)
HIV-specific antigens	CD4 binding site (NIH45-46, 3BNC60, VRC01) glycan/V3 loop (10–1074, PGT121) gp41 (10E8, 4E10)
HIV binding sites on CD4+ T cells	CD4 (ibalizumab) CCR5 (PRO140)
CD4-negative cell-bound virus	CD18
Host derived antigens on both free virus and cells	CD36 LFA-1/CD11a (MEM30) TSG101 (CB8-2) GM3 (DH2) ICAM-1
Uninfected dendritic cells	CD169
Reproductive-tract-coating antigens	SAGA-1, male-tract-specific glycoform of CD52 (H6-3C4, S19)