Table 1.
Neutralization Activity of Broadly Neutralizing Human Immunodeficiency Virus (HIV) Antibodies in Cell-Associated HIV Transmission Assays
| Reference | System | CD4bs (VRCO1, b12) | gp41 MPER (4 E10, 2F5) |
|---|---|---|---|
| Frankel et al [25] | DC-T | + | + |
| Abela et al [26] | PBMC-TZMbl | − | + |
| Malbec et al [27] | T-T | + | − |
| Sagar et al [22] | DC-T | - | + |
| Duncan et al [28] | MDM-T | + | − |
| Martin et al [29] | Jurkat/A301.R5 | + | + |
| Zhong et al [30] | Jurkat/SupT | ND | + |
Abbreviations: +, strong neutralization in both cell-free and cell-associated HIV transmission assays; −, poor neutralization activity in cell-associated HIV transmission assays.