Table 1.
Identification of 32 genes associated with poor response to aromatase inhibitor therapy
| Gene | Name | In vitro | Clinical | ||
|---|---|---|---|---|---|
| Fold change | P -value | Correlation coefficient | P -value | ||
| ACTR2 | ARP2 actin-related 2 homolog (yeast) | 1.82 | 2.74E-05 | -0.378 | 9.68E-04 |
| AP1B1 | Adaptor-related protein complex 1, β1 subunit | 1.67 | 6.25E-04 | -0.398 | 4.96E-04 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 1.60 | 1.36E-04 | -0.352 | 2.25E-03 |
| CCM2 | Cerebral cavernous malformation 2 | 1.94 | 5.07E-05 | -0.36 | 1.72E-03 |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | 1.51 | 5.05E-04 | -0.302 | 9.26E-03 |
| DTX2 | Deltex homolog 2 (Drosophila) | 2.24 | 8.19E-04 | -0.338 | 3.41E-03 |
| EML4 | Echinoderm microtubule–associated protein–like 4 | 2.50 | 1.60E-06 | -0.336 | 3.59E-03 |
| FAM38A | Family with sequence similarity 38, member A | 3.59 | 5.02E-05 | -0.338 | 3.42E-03 |
| FBXL10 | Lysine (K)-specific demethylase 2B | 3.12 | 8.80E-06 | -0.3 | 9.70E-03 |
| IFNAR2 | Interferon (α, β and ω) receptor 2 | 1.50 | 2.36E-04 | -0.313 | 6.79E-03 |
| IFNGR1 | Interferon γ receptor 1 | 1.85 | 1.02E-04 | -0.356 | 1.99E-03 |
| IGF2R | Insulin-like growth factor 2 receptor | 2.93 | 1.20E-06 | -0.319 | 5.84E-03 |
| KIAA0513 | KIAA0513 | 4.21 | 2.42E-04 | -0.379 | 9.43E-04 |
| LILRB1 | Leukocyte immunoglobulin-like receptor, subfamily B, member 1 | 1.61 | 1.77E-04 | -0.389 | 6.80E-04 |
| LILRB3 | Leukocyte immunoglobulin-like receptor, subfamily B, member 3 | 2.06 | 2.50E-06 | -0.366 | 1.42E-03 |
| MAP3K7 | Mitogen-activated protein kinase 7 | 1.97 | 7.90E-06 | -0.334 | 3.84E-03 |
| MFHAS1 | Malignant fibrous histiocytoma-amplified sequence 1 | 2.11 | 1.79E-05 | -0.299 | 9.76E-03 |
| MGAT1 | Mannosyl glycoprotein acetylglucosaminyltransferase | 1.70 | 1.33E-04 | -0.313 | 6.78E-03 |
| MICAL1 | Microtubule-associated monooxygenase, calponin/LIM domain | 2.43 | 7.00E-07 | -0.385 | 7.65E-04 |
| NPC2 | Niemann-Pick disease, type C2 | 2.37 | 3.09E-05 | -0.421 | 2.12E-04 |
| PHACTR2 | Phosphatase and actin regulator 2 | 3.20 | 1.22E-05 | -0.35 | 2.39E-03 |
| PLEKHF1 | Pleckstrin homology domain containing, family F, member 1 | 2.13 | 3.51E-05 | -0.369 | 1.31E-03 |
| RGS19 | Regular of G-protein signaling 19 | 1.52 | 7.14E-04 | -0.474 | 2.54E-05 |
| SLC15A4 | Solute carrier family 15, member 4 | 1.54 | 9.13E-05 | -0.307 | 7.91E-03 |
| ST8SIA4 | ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 4 | 2.45 | 2.74E-04 | -0.32 | 5.64E-03 |
| TNRC6B | Trinucleotide repeat containing 6B | 2.13 | 1.90E-04 | -0.3 | 9.74E-03 |
| TTYH3 | Tweety homolog 3 (Drosophila) | 2.72 | 4.65E-04 | -0.408 | 3.42E-04 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 2.27 | 3.00E-06 | -0.349 | 2.40E-03 |
| XPO6 | Exportin 6 | 1.80 | 4.64E-04 | -0.312 | 6.99E-03 |
| YWHAH | Tyrosine/tryptophan monooxygenase activation protein | 1.44 | 4.83E-04 | -0.365 | 1.50E-03 |
| ZBED4 | Zinc finger, BED-type containing 4 | 1.59 | 5.93E-05 | -0.337 | 3.48E-03 |
| ZCCHC11 | Zinc finger, CCHC domain containing 11 | 1.36 | 4.75E-04 | -0.433 | 1.36E-04 |