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. 2014 Oct 24;16:465. doi: 10.1186/s13058-014-0465-z

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© Li et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Transducin (β)-like 1 X-linked receptor 1 (TBLR1) contributes to breast cancer progression in vitro and in vivo . (A and B) Anchorage-independent growth assays in TBLR1-overexpressing cells and TBLR1-silenced cells, respectively. Quantification of the soft agar colony formations was based on colonies >0.1 mm in diameter after 10 days of culture. (C-E) Xenograft model in nude mice inoculated with either TBLR1-overexpressing or TBLR1-knockdown breast cancer cells, or their respective vector control cells (n =5/group) 42 days after inoculation. (C) Growth curves showing changes in tumor volume; (D) images showing changes in tumor size; (E) mean tumor weights. (F) H&E and immunohistochemical staining showed that overexpression of TBLR1 induced, whereas suppression of TBLR1 inhibited, the tumorigenicity of breast cancer cells in vivo, as indicated by the percentage of Ki-67 positive cells. All data are presented as mean ± SD of three independent experiments; *P <0.05.