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. 2014 Jun 14;3(4):1010–1024. doi: 10.1002/cam4.269

Figure 8.

Figure 8

Kaplan–Meier survival curves for skin versus nonskin IVL patients. Patients with skin IVL had significantly better survival than nonskin patients in (A) time from initial presentation of symptoms to death but not (C) time from diagnosis to death, (E) time from treatment to death, or (G) time from treatment to first recurrence. (B) The difference between skin and nonskin IVL remains significant in each successive decade for median time from initial presentation of symptoms to death in the 1960–1980s (skin versus nonskin: 15.0 [range 5.0–31.7, n = 14] versus 4.0 [range 0.3–33.0, n = 44] months [P = 0.0001]), 1990s (skin versus nonskin: 12.0 [range 1.7–69.0, n = 32] versus 6.2 [range 0.1–87.0, n = 134] months [P = 0.0211]), and 2000s (skin versus nonskin: 20.0 [range 1.0-110.0, n = 66] versus 10.0 [range 0.1–92.0, n = 262] months [P = 0.0007]). For skin IVL, the difference was not significant between decades 1960–1980s and 1990s (P = 0.3848) or 1960–1990s and 2000s (P = 0.1158). (D) For median time from diagnosis to death in the 1960–1980s, there was significant difference between skin and nonskin IVL: 19.9 (range 2.1–42.0, n = 10) versus 10.0 (range 0.5–27.0, n = 10) months (P = 0.0445). No difference was found in 1990s (P = 0.3287) and 2000s (P = 0.2946). Comparing skin IVL between decades, the difference was not significant between decades 1960–1980s and 1990s (P = 0.9185) or 1960–1990s and 2000s (P = 0.6318). (F) For median time from treatment to death, there was no difference between skin and nonskin IVL in the 1960–1980s (P = 0.5492), 1990s (P = 0.3695), and 2000s (P = 0.5190). Comparing skin IVL between decades, there is also no difference between decades 1960-1980s and 1990s (P = 0.8617) or 1960–1990s and 2000s (P = 0.3601). (H) For median time from treatment to first recurrence, there is no difference between skin and nonskin IVL in the 1960-1980s (P = 0.5151), 1990s (P = 0.4654), and 2000s (P = 0.7491). Comparing skin IVL between decades, there is also no difference between decades 1960-1980s and 1990s (P = 0.6912) or 1960-1990s and 2000s (P = 0.3191). IVL, intravascular lymphomatosis.