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Tumors in ApcMin/+ mice, with and without Ptgdr knockouts (total, small, large, and colon). (A) Tumors at 6 weeks. (B) Tumors at 14 weeks. +/+, control ApcMin/+ mice. +/− and −/−, ApcMin/+ mice with heterozygous and homozygous Ptgdr knockouts, respectively. Filled symbols: females. Open symbols: males. Horizontal bars: medians. *P < 0.025. See Tables S1 and S2 for details.
